Publications
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Chao, W.C.H.*, Wade, B.O.*, Bouchoux, C., Jones, A.W., Purkiss, A.G., Federico, S., O’Reilly, N., Snijders, A.P., Uhlmann, F., and Singleton, M.R. (2017). Structural basis of Eco1-mediated cohesin acetylation. Sci. Rep. 7:44313. doi:10.1038/srep44313
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Sansregret, L., Patterson, J.O., Dewhurst, S., López-García, C., Koch, A., McGranahan, N., Chao, W.C.H., Barry, D.J., Rowan, A., Instrell, R., Horswell, S., Way, M., Howell, M., Singleton, M.R., Medema, R.H., Nurse, P., Petronczki, M., Swanton, C. (2017). APC/C dysfunction limits excessive cancer chromosomal instability. Cancer Discov. 7(2); 1–16
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Chao, W.C.H., Murayama, Y., Muñoz, S., Jones, A.W., Wade, B.O., Purkiss, A.G., Hu, X.-W., Borg, A., Snijders, A.P., Uhlmann, F., Singleton, M.R. (2017). Structure of the cohesin loader Scc2. Nat. Commun. 8, 13952.
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Chao, W.C.H., Murayama, Y., Muñoz, S., Costa, A., Uhlmann, F., and Singleton, M.R. (2015). Structural studies reveal the functional modularity of the Scc2-Scc4 cohesin loader. Cell Rep. 12, 719–725.
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Drosopoulos, K., Tang, C., Chao, W.C.H., and Linardopoulos, S. (2014). APC/C is an essential regulator of centrosome clustering. Nat. Commun. 5, 3686.
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He, J.*, Chao, W.C.H.*, Zhang, Z., Yang, J., Cronin, N., and Barford, D. (2013). Insights into degron recognition by APC/C coactivators from the structure of an Acm1-Cdh1 complex. Mol. Cell 50, 649–660.
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Ferguson, J.L., Chao, W.C.H., Lee, E., and Friedman, K.L. (2013). The anaphase promoting complex contributes to the degradation of the S. cerevisiae telomerase recruitment subunit Est1p. PLoS ONE 8, e55055.
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Zhang, Z., Yang, J., Kong, E.H., Chao, W.C.H., Morris, E.P., da Fonseca, P.C.A., and Barford, D. (2013). Recombinant expression, reconstitution and structure of human anaphase-promoting complex (APC/C). Biochem. J. 449, 365–371.
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Chao, W.C.H.*, Kulkarni, K.*, Zhang, Z., Kong, E.H., and Barford, D. (2012). Structure of the mitotic checkpoint complex. Nature 484, 208–213.
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Brennan, D.F., Dar, A.C., Hertz, N.T., Chao, W.C.H., Burlingame, A.L., Shokat, K.M., and Barford, D. (2011). A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK. Nature 472, 366–369.
*co-first authorships